Sheffield United boss Heckingbottom will be without the services of striker Oliver McBurnie, as he was sent off in their recent match against Spurs so he is serving a one-match ban here.
Rhys Norrington-Davies is back in training, but he is unlikely to start on Sunday. Rhian Brewster, Max Lowe, William Osula, George Baldock and John Fleck remain sidelined and will miss this key encounter against Newcastle.
Newcastle boss Eddie Howe will be unable to call upon the services of midfielders Joe Willock (hamstring) and Joelinton, the latter of whom is facing an extended spell on the sidelines with a knee injury.
The Englishman is expected to reshuffle his attack and midfield once again as he looks to manage the workload of his players with Champions League fixtures coming into play, with the likes of Miguel Almiron, Elliot Anderson and Callum Wilson strong candidates to come into the starting XI.
Howe may be forced to rest Kieran Trippier at some stage, given the recent hectic schedule, and with Valentino Livramento pushing to make his first start since arriving from Southampton in the summer transfer window.